Testosterone impact on the liver–Expert’s session on fatty liver disease


Testosterone is an important anabolic hormone, with impacts on bone, muscle, and hematopoiesis. Lots of the qualities of liver disease are like those found in hypogonadal men, such as sarcopenia, osteoporosis, obesity, gynecomastia, and reduced libido. On the other hand, the relative involvement of testosterone deficiency to the symptomatology of liver disease hasn’t been well recognized.


Serum testosterone has been reduced up to 90 percent of men with cirrhosis, with amounts decreasing as liver disease increases. More recently, it’s been shown that low testosterone in men with cirrhosis is associated with greater mortality, independent of their recognized prognostic variables, like the Model for End-Stage Liver Disease score.

Testosterone Therapy and its side effects

Testosterone treatment, or hormone replacement therapy (HRT) does have intermittent side effects which need to be discussed with your physician. It’s interesting because the majority of the anxieties that men have when contemplating testosterone treatment are sporadic and a few of the common things would not cross their mind. As an instance, most men are worried that their testosterone production may entirely shut off or they are going to have significant testicular shrinkage.

Typically, exogenous testosterone may be considered “supplemental” rather than at the “replacement” category. Outstanding physicians test your testosterone levels once you have gone on HRT and will be certain your testosterone levels aren’t too high. In substantiality, these are often not a problem because most men continue to make some testosterone when on testosterone treatment.

How testosterone impact the liver?

Just about all testosterones given in testosterone treatment are extremely well-tolerated by the liver. However, you would like a physician that can test your liver function merely to play it safe. Liver problems are associated almost exclusively with the old-line oral testosterones which were hard to metabolize.In the subsequent paragraphs let’s take a look at testosterone impact on the liver and gall bladder.


Among the dangers related to this sort of hormone therapy is a compromise of liver functioning. Cancerous and non-cancerous cysts and tumors may show up on the liver, particularly if the treatment of testosterone is protracted.

The liver doesn’t make hormones because these are created in the several different glands in the body and also not lots of people relate their liver with their hormones. The reality is the liver plays a primary role in hormonal imbalance since the liver breaks down or metabolizes the hormones as soon as they’ve done their work within the body.

The liver breaks down the set of hormones called the steroid hormones that include –

  • The sex hormones that control our sexual life and body contour
  • Aldosterone which modulates the balance of these minerals potassium and sodium and water from the body
  • Cortisone that modulates the immune system

If aldosterone isn’t broken down efficiently, this may lead to fluid retention, and several female find this is an issue. Fluid retention may result in uncomfortable puffiness, an aggravation of cellulite and weight reduction. Also, it can increase the blood pressure.

What is fatty liver disease?

This disease is emphasized by fat accumulating on your liver, and this has been demonstrated in research to contribute to inflammation and discoloration of your liver.


Fatty liver disorder, commonly found in alcoholics and morbidly obese people, is a disease that affects your liver, boosting your health hazard.

High levels of visceral fat, also in conjunction with insulin resistance, have been connected to increased fat accumulation in your liver.

Fatty liver in postmenopausal women caused by High testosterone

Researchers found that elevated levels of bioavailable testosterone in postmenopausal women increases their risk of nonalcoholic fatty liver disease (NAFLD). The researchers stated, “To our understanding, this is the most meaningful study to date demonstrating the institution of circulating multiple sexual hormone levels with liver fat, as quantified using scan, at a population-based multi-ethnic sample of both women and men.”

What is the relation between Low Testosterone and Advanced Liver Disease?

However, the comparative involvement of testosterone deficiency to the complex liver disease hasn’t been well recognized. More recently it’s been shown that low testosterone in males with cirrhosis is associated with greater mortality, independent of those classically recognized prognostic factors like MELD score. Recently, several small clinical trials have analyzed the function of testosterone therapy in men who have cirrhosis, none of which have solved the matter of whether testosterone is advantageous.

Females having the most bioavailable testosterone have been prone to have a fatty liver in comparison to women with low testosterone levels. Similarly, men with higher testosterone also had fatty livers in contrast to men with lower readings. But the men with higher SHBG were not as likely to have fatty livers in contrast to people with low SHBG.


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